広島大学千原研究室

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研究業績

2017年

  • Sakuma, C. and Chihara, T.“Role of the STRIPAK complex and the Hippo pathway in synaptic terminal formation”
    Neural Regen Res12:578-579 (2017)
  • 佐久間知佐子、千原崇裕「小胞輸送・微小管安定性・Hippoシグナル経路に関わるハブタンパク質Strip」
    生化学 89, 424-427 (2017)

2016年

  • Sakuma, C., Saito, Y., Umehara, T., Kamimura, K., Maeda, N., Mosca, T.J., Miura, M. and Chihara, T. “The Strip-Hippo pathway regulates synaptic terminal formation by modulating actin organization at the Drosophila neuromuscular synapses”
    Cell Rep 16:2289-2297 (2016)
    プレスリリース
  • Miyake, N., Fukai, R., Ohba, C., Chihara, T., Miura, M., Shimizu, H., Kakita, A., Imagawa, E., Shiina, M., Ogata, K., Okuno-Yuguchi, J., Fueki, N., Ogiso, Y., Suzumura, H., Watabe, Y., Imataka, G., Leong, HY., Fattal-Valevski, A., Kramer, U., Miyatake, S., Kato, M., Okamoto, N., Sato, Y., Mitsuhashi, S., Nishino, I., Kaneko, N., Nishiyama, A., Tamura, T., Mizuguchi, T., Nakashima, M., Tanaka, F., Saitsu, H. and Matsumoto, N. “Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy”
    Am J Hum Genet 99:950-961 (2016)
  • Okumura, M., and Chihara, T. “Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development”
    Neural Regen Res11:1394-1395 (2016)
  • Matsukawa, K., Hashimoto, T., Matsumoto, T., Ihara, R., Chihara, T., Miura, M., Wakabayashi, T. and Iwatsubo, T. “Familial ALS-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila Melanogaster through an Increase in the Cytoplasmic Localization of TDP-43”
    J Biol Chem291:23464-23476 (2016)
  • Kashio, S., Obata, F., Zhang, L., Katsuyama, T., Chihara, T. and Miura, M. “Tissue non-autonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila
    Proc Natl Acad Sci U S A 113:1835-1840 (2016)
  • Okumura, M., Kato, T., Miura, M. and Chihara, T. “Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos”
    Genes Cells 21:53-64 (2016)
  • Lightfoot, JW., Wilecki, M., Okumura, M. and Sommer RJ. “Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes”
    J Vis Exp 4:doi: 10.3791/54404 (2016)

2015年

  • Sakuma, C., Okumura, M., Umehara, T., Miura, M. and Chihara, T. “A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability”
    Sci Rep 5:17769 (2015)
  • Okumura, M., Sakuma, C., Miura, M. and Chihara, T. “Linking cell surface receptors to microtubules: Tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis”
    J Neurosci 35:1979-1990 (2015)
  • Okumura, M., Miura, M. and Chihara, T. “The roles of tubulin-folding cofactors in neuronal morphogenesis and disease”
    Neural Regen Res, 10: 1388-1389 (2015)
  • Kondo, T., Okada, M., Kunihiro, K., Takahashi, M., Yaoita, Y., Hosoya, H. and Hamao, K.  “Characterization of myosin II regulatory light chain isoforms in HeLa cells”
    Cytoskeleton (Hoboken) 72: 609-20 (2015)
  • Hosoba, K., Komatsu, S., Ikebe, M., Kotani, M., Wenqin, X., Tachibana, T., Hosoya, H. and Hamao, K. “Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells”
    Biochem Biophys Res Commun. 459: 686-91 (2015)
  • 佐久間知佐子、千原崇裕「細胞内輸送に関わる新しい分子Strip」
    医学のあゆみ 254: 1185-1186 (2015)
  • 千原崇裕、三浦正幸「脳科学辞典 (2015)」(以下の執筆を担当:ノザンブロット: 10.14931/bsd.5862、アンチセンス法: DOI:10.14931/bsd.5864、モルフォリノ: DOI:10.14931/bsd.5880)

2014年

  • Sakuma, C., Kawauchi, T., Haraguchi, S., Shikanai, M., Yamaguchi, Y., Gelfand, V.I., Luo, L. and Miura, M. and Chihara, T.  “Drosophila Strip serves as a platform for early endosome organization during axon elongation”
    Nat Commun 5: 5180 (2014)
    プレスリリース
  • Chihara, T., Kitabayashi, A., Morimoto, M., Takeuchi, K., Masuyama, K., Tonoki, A., Davis, L.D., Wang, J.W. and Miura, M. “Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila
    PLOS Genetics 10: e1004437 (2014)
    プレスリリース
  • Sakuma, C., Anzo, M., Miura, M. and Chihara, T. “Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit”
    Genes and Genetic Systems 89: 17-26 (2014)
  • 千原崇裕「膜タンパク質を一網打尽:小胞体分子Meigoによる樹状突起ターゲティング制御機構」
    生化学 86, 259-264 (2014)

2013年

  • Sekine, S.U., Haraguchi, S., Chao, K., Kato, T., Luo, L., Miura, M. and Chihara, T. “Meigo governs dendrite targeting specificity by modulating Ephrin level and N-glycosylation”
    Nat Neurosci 16:683-91 (2013)
    プレスリリース
  • Ihara, R., Matsukawa, K., Nagata, Y., Kunugi, H., Tsuji, S., Chihara, T., Kuranaga, E., Miura, M., Wakabayashi, T., Hashimoto, T. and Iwatusbo, T. “RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy”
    Hum. Mol. Genet. 22:4474-84 (2013)
  • Kondo, T., Isoda, R., Ookusa, T., Kamijo, K., Hamao, K. and Hosoya, H. “Aurora B but not Rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis”
    PLoS One. 8: e70965 (2013)
  • 関根清薫・千原崇裕「小胞体タンパク質MeigoはEphrinの蛋白質量およびN-結合型糖鎖修飾を介し樹状突起のターゲティングにおける特異性を制御する」
    ライフサイエンス新着論文レビュー(http://first.lifesciencedb.jp/archives/7116), 2013

2012年

  • Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T. Miura, M., Ichijo, H. and Takeda, K. “Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster
    PLOS ONE 7:e30265 (2012)
  • Kondo, T., Itakura, S., Hamao, K. and Hosoya, H. “Phosphorylation of myosin II regulatory light chain controls its accumulation, not that of actin, at the contractile ring in HeLa cells”
    Exp Cell Res 318: 915-24 (2012)
  • Kondo, T., Isoda, R., Uchimura, T., Sugiyama, M., Hamao, K. and Hosoya, H. “Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis”
    Biochem Biophys Res Commun 417: 686-91 (2012)

2011年

  • Kondo, T., Hamao, K., Kamijo, K., Kimura, H., Morita, M., Takahashi, M. and Hosoya, H. “Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells”
    Biochem J 435: 569-76 (2011)

2010年以前

  • Tea, J.S., Chihara, T. and Luo, L. “Histon deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero”
    J Neurosci 21:9939-9946 (2010)
  • Lin, S., Lai, S.L., Yu, H.H., Chihara, T., Luo, L. and Lee, T. “Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain”
    Development 137: 43-51 (2010)
  • Morita, M., Hamao, K., Izumi, S., Okumura, E., Tanaka, K., Kishimoto, T. and Hosoya, H. “Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?”
    J Biochem 148: 533-8 (2010)
  • Sekine, S., Miura, M. and Chihara, T.* “Organelles in developing neurons: essential regulators of neuronal morphogenesis and function”
    Int. J. Dev. Biol. 53: 19-27 (2009)
  • Asano, S., Hamao, K. and Hosoya, H. “Direct evidence for roles of phosphorylated regulatory light chain of myosin II in furrow ingression during cytokinesis in HeLa cells”
    Genes Cells 14: 555-68 (2009)
  • Hamao, K., Morita, M. and Hosoya, H. “New function of the proline rich domain in dynamin-2 to negatively regulates its interaction with microtubules in mammalian cells”
    Exp Cell Res 315: 1336-45 (2009)
  • Chihara, T., Luginbuhl, D. and Luo, L. “Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization”
    Nat Neurosci. 10: 828-837 (2007)
  • Kishida, S.,# Hamao, K.,# Inoue, M., Hasegawa, M., Matsuura, Y., Mikoshiba, K., Fukuda, M. and Kikuchi, A. “Dvl regulates endo- and exocytotic processes through binding to synaptotagmin”
    Genes Cells 12: 49-61. (2007)(# equal contributor)
  • 千原崇裕「樹状突起はミトコンドリア不全に敏感!? 神経突起の形を制御するタンパク質合成とミトコンドリア」
    細胞工学 Vol. 26 No. 9 1048-9 (2007)
  • Berdnik, D., Chihara, T., Couto, A. and Luo, L.“Wiring stability of the adult Drosophila olfactory circuit after lesion”
    J. Neurosci. 26: 3367-3376 (2006)
  • Beningo, K.A., Hamao, K., Dembo, M., Wang, Y.L. and Hosoya, H. “Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase”
    Arch. Biochem. Biophys 456: 224-31 (2006)
  • Kato, K., Chihara, T. and Hayashi, S. “Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea”
    Development 131: 5253-5261 (2004)
  • Chihara, T. and Luo, L. “Like poles repel: Molecular mechanisms of dendritic tiling”
    Cell 119: 148-9 (2004)
  • Chihara, T., Kato, K., Taniguchi, M., Ng, J. and Hayashi, S. “Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila
    Development 130: 1419-1428 (2003)
  • Ueda, K. (旧姓), Ohta, Y. and Hosoya, H. “The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A”
    Biochem. Biophys. Res. Commun 301: 886-90 (2003)
  • Fumoto, K., Uchimura, T., Iwasaki, T. and Ueda, K. (旧姓) and Hosoya, H. “Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge”
    Biochem. J 370: 551-6 (2003)
  • Uchimura, T., Fumoto, K., Yamamoto, Y., Ueda, K. (旧姓) and Hosoya, H. “Spatial localization of mono-and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells”
    Cell Struct. Funct 27: 479-86 (2002)
  • Ueda, K. (旧姓), Murata-Hori, M., Tatsuka, M. and Hosoya H. “Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells”
    Oncogene 21: 5852-60 (2002)
  • Suizu, F., Fukuta, Y., Ueda, K. (旧姓), Iwasaki, T., Tokumitsu, H. and Hosoya, H. “Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo”
    Biochem. J 367: 335-45 (2002)
  • Gerashchenko, B.I., Ueda, K. (旧姓), Hino, M. and Hosoya, H. “Phosphorylation at threonine-18 in addition to phosphorylation at serine-19 on myosin-II regulatory light chain is a mitosis-specific event”
    Cytometry 47: 150-7 (2002)
  • Murata-Hori, M., Fukuta, Y., Ueda, K. (旧姓), Iwasaki, T. and Hosoya, H. “HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells”
    Oncogene 20: 8175-83 (2001)
  • Saitoh, T., Takemura, S., Ueda, K .(旧姓), Hosoya, H., Nagayama, M., Haga, H., Kawabata, K., Yamagishi, A. and Takahashi, M. “Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts”
    FEBS Lett. 509: 365-9 (2001)
  • Chihara, T. and Hayashi, S. “Control of tracheal tubulogenesis by Wingless signaling”
    Development 127: 4433-4442 (2000)
  • Suizu, F., Ueda, K. (旧姓), Iwasaki, T., Murata-Hori, M. and Hosoya, H. “Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1b (RSK-2)”
    J Biochem 128: 435-40 (2000)
  • Kai, H., Hisatsune, A., Chihara, T., Uto, A., Kokusho, A., Miyata, T. and Basbaum, C. “Myeloid ELF-1-like factor up-regulates lysozyme transcription in epithelial cells”
    J. Biol. Chem. 274: 20098-20102 (1999)
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